2020 Selby Research Awards
The Selby Research Awards are granted annually by both the The University of Melbourne and The University of Sydney. The award is to assist an outstanding academic establish his or her research career. The Foundation congratulates:
Dr Eirini Goudeli
Department of Chemical Engineering
University of Melbourne
Awarded on 01/04/2020
Project: Molecular Understanding of Soot Energetics and Kinetics
Although soot is one of the most impactful by-products of hydrocarbon combustion, there is still a significant knowledge gap in our understanding of its formation mechanism, which often leads to erroneous predictions of the macroscopic properties of soot. In fact, the details of soot formation have been the subject of considerable debate over the years. The proposed work aims to investigate the physics and reaction pathways that result in soot formation and growth in combustion processes starting from atomistic first principle simulations.
Soot is an unavoidable by-product of combustion which will remain the prime source of energy production for the foreseeable future. The presence of soot not only affects energy efficiency, but also affects public health and environment. Unravelling the underlying mechanisms of soot formation and growth will contribute in the design of new bona fide routes to eliminate the amount of waste by-product production and energy consumption and reduce pollutant emissions.
The proposed research will offer a molecular-level understanding of soot formation processes that will assist in building cleaner combustion devices and will help us quantify the effects of anthropogenic emissions on climate change, by providing a better characterization of emitted soot from combustion.Back to Top
Dr William Jorgensen
School of Chemistry
University of Sydney
Awarded on 01/02/2021
Neuropathic pain is a complex, chronic pain state affecting 1 in 5 Australians and costingsociety $34 billion annually. Less than half of these patients obtain clinically relevant painrelief re-enforcing its unmet medical need. There is a need for novel therapeutics to remedythis significant problem. Ion channel receptors are important drug targets. Despite their welldocumented involvement in various disease states, only 20% of the 400 known ion channelreceptors have marketed drugs. This presents a niche opportunity to target an underexploitedarea of research to develop new therapeutics.
This project focuses on two distinct receptor classes, the purinergic 2X4 (P2X4) receptor andthe glycine receptor (GlyR). These receptors have both shown to modulate pain signallingwithin the central nervous system. Recent advances have identified new classes of moleculeswith unique activity and binding properties at these receptors. The proposed plan involves thecontinual progression of such molecules towards clinically relevant outcomes for patients,whilst continuing to expand on the compound libraries to mitigate any potential pit-fallscommon amongst the drug discovery pipe-line.Back to Top